Metabolomics-on-a-Chip of Hepatotoxicity Induced by Anticancer Drug Flutamide and Its Active Metabolite Hydroxyflutamide Using HepG2/C3a Microfluidic Biochips
نویسندگان
چکیده
منابع مشابه
comparative dna interaction studies of antiviral drug, zidovudine and its complex using different instrumental methods
هدف از این مطالعه بررسی امکان استفاده از داروهای شناخته شده در درمان سایر بیماریها به عنوان داروهای ضد سرطان است. همچنین با استفاده از این داروها در ساختمان کمپلکس فلز می توان شاخص های دارویی بدست آمده را بررسی نمود. داروی ضد ویروس ایدز(hiv)به نام زیدوودین(azt)انتخاب و.کمپلکس.محلول.در.آب[pt(azt)2]cl2سنتزو به روشهای مختلف فیزیکی و شیمیایی شناسایی گردید. بر هم کنش مقایسه ای این دارو و کمپلکس پلا...
15 صفحه اولFlutamide-induced hepatotoxicity
Abstract. – OBJECTIVE: Flutamide (FLU) is a non-steroidal antiandrogen drug approved for the treatment of advanced prostate cancer. While this indication limits the use to male patients, FLU is widely prescribed to women, off-label, for the treatment of polycystic ovary syndrome (POCS) related hirsutism and acne. According to the literature, its assumption is associated with a higher incidence ...
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flutamide is a non-steroidal antiandrogen commonly used in the treatment of prostate cancer. severe hepatotoxicity occurs in few patients, yet may be fatal. to date, none of the reported cases of flutamide hepatotoxicity has demonstrated thrombocytopenia and chronic liver disease. we report the case of a 55-year-old male with prostatic adenocarcinoma who developed liver failure after six months...
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Historically, DNA molecules have been known as the building blocks of life, later on in 1994, Leonard Adelman introduced a technique to utilize DNA molecules for a new kind of computation. According to the massive parallelism, huge storage capacity and the ability of using the DNA molecules inside the living tissue, this type of computation is applied in many application areas such as me...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2012
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfs230